30 products were found matching "K04207"!

L-152,804 is an antagonist of neuropeptide Y (NPY) receptor Y5 (IC50s = 26 and 31 nM for the human and rat receptors, respectively). It is selective for Y5 over Y1, Y2, and Y4 receptors (IC50s = >10,000 nM for the human receptors). L-152,804 (30 µg, i.c.v.) reduces bovine pancreatic peptide-induced, but not...

NTNCB is an antagonist of neuropeptide Y (NPY) receptor Y5 (Ki = 8 nM). It is selective for neuropeptide Y5 over Y1 receptors (Ki = >10,000 nM). NTNCB (10 and 20 µM) suppresses colony formation by PC3 and DU145 prostate cancer cells. In vivo, NTNCB (1, 3, and 10 mg/kg per day) reduces tumor volume in a PC3 mouse...

Description: CGP71683 hydrochloride (CGP71683A) is a competitive neuropeptide Y5 receptor antagonist (Ki: 1.3 nM) and shows no obvious activity at Y1 receptor (Ki >4000 nM) and Y2 receptor (Ki: 200 nM) in cell membranes. Target: Neuropeptide Y Receptor. Smiles:...

Description: MK-0557 is a selective and orally available antagonist of the neuropeptide Y5 receptor (Ki: 1.6 nM). Target: Neuropeptide Y Receptor. Smiles: Fc1ccccc1-n1ccc(NC(=O)[C@H]2CC[C@]3(CC2)OC(=O)c2ccncc32)n1. References: Fichtner M, et al. Discovery and evaluation of spirocyclic derivatives as antagonists of...

Description: Velneperit (S2367) is potent and selective neuropeptide Y (NPY) Y5 receptor under evaluating for treatment of obesity. Target: Neuropeptide Y Receptor. Smiles: CC(C)(C)S(=O)(=O)N[C@H]1CC[C@@H](CC1)C(=O)Nc1ccc(cn1)C(F)(F)F. References: George M , Rajaram M , Shanmugam E . New and emerging drug molecules...

Host Species: Rabbit. Isotype: IgG. Buffer: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific...

MK-0557 is a potent antagonist of the neuropeptide Y (NPY) receptor Y5 (Kis = 1.3, 0.79, 0.74, and 1.4 nM for human, rhesus monkey, mouse, and rat receptors, respectively). It is >7,500-fold selective for Y5 over other receptors and lacks activity in a panel of 180 receptors, enzymes, and ion channels at...

Protein function: Receptor for neuropeptide Y and peptide YY. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity. Seems to be associated with food intake. Could be involved in feeding disorders. [The UniProt Consortium]

0.5 mg/ml in 1X TBS, pH7.3, with 0.5% BSA (US sourced) and 0.02% sodium azide. Additional name(s) for this target protein: Neuropeptide Y receptor Y5 Protein function: Receptor for neuropeptide Y and peptide YY. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity. Seems to...

[Leu31,Pro34] Neuropeptide Y (NPY) is an agonist of the NPY receptors Y1 and Y5 with Ki values of 0.11 and 0.17 nM, respectively, for human and 0.08 and 0.18 nM, respectively, for rhesus monkey receptors. It reduces forskolin-induced cAMP accumulation in L-M(TK-) cells expressing human and rat Y4 receptors (EC50s =...

CGP 71683 is an antagonist of neuropeptide Y (NPY) receptor Y5 (IC50 = 1.4 nM in a radioligand binding assay). It is selective for Y5 over Y1, Y2, and Y4 receptors (IC50s = 2,765, 7,187, and 5,637 nM, respectively). It inhibits NPY-induced increases in BT-549 cell growth and MDA-MB-231 cell migration when used at a...