35 products were found matching "K04207"!

Lu AA33810 is an antagonist of neuropeptide Y (NPY) receptor Y5 (Ki = 1. nM for the human receptor). It is selective for Y5 over Y1, Y2, and Y4 (Kis = >10 µM for all in HEK293 membranes expressing rat receptors). Lu AA33810 also binds the serotonin (5-HT) receptor subtypes 5-HT1A and 5-HT2B (Kis = 478 and 247 nM,...

0.5 mg/ml in 1X TBS, pH7.3, with 0.5% BSA (US sourced) and 0.02% sodium azide. Additional name(s) for this target protein: Neuropeptide Y receptor Y5

L-152,804 is an antagonist of neuropeptide Y (NPY) receptor Y5 (IC50s = 26 and 31 nM for the human and rat receptors, respectively). It is selective for Y5 over Y1, Y2, and Y4 receptors (IC50s = >10,000 nM for the human receptors). L-152,804 (30 µg, i.c.v.) reduces bovine pancreatic peptide-induced, but not...

NTNCB is an antagonist of neuropeptide Y (NPY) receptor Y5 (Ki = 8 nM). It is selective for neuropeptide Y5 over Y1 receptors (Ki = >10,000 nM). NTNCB (10 and 20 µM) suppresses colony formation by PC3 and DU145 prostate cancer cells. In vivo, NTNCB (1, 3, and 10 mg/kg per day) reduces tumor volume in a PC3 mouse...

MK-0557 is a potent antagonist of the neuropeptide Y (NPY) receptor Y5 (Kis = 1.3, 0.79, 0.74, and 1.4 nM for human, rhesus monkey, mouse, and rat receptors, respectively). It is >7,500-fold selective for Y5 over other receptors and lacks activity in a panel of 180 receptors, enzymes, and ion channels at...

Protein function: Receptor for neuropeptide Y and peptide YY. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity. Seems to be associated with food intake. Could be involved in feeding disorders. [The UniProt Consortium]

0.5 mg/ml in 1X TBS, pH7.3, with 0.5% BSA (US sourced) and 0.02% sodium azide. Additional name(s) for this target protein: Neuropeptide Y receptor Y5 Protein function: Receptor for neuropeptide Y and peptide YY. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity. Seems to...

[Leu31,Pro34] Neuropeptide Y (NPY) is an agonist of the NPY receptors Y1 and Y5 with Ki values of 0.11 and 0.17 nM, respectively, for human and 0.08 and 0.18 nM, respectively, for rhesus monkey receptors. It reduces forskolin-induced cAMP accumulation in L-M(TK-) cells expressing human and rat Y4 receptors (EC50s =...

CGP 71683 is an antagonist of neuropeptide Y (NPY) receptor Y5 (IC50 = 1.4 nM in a radioligand binding assay). It is selective for Y5 over Y1, Y2, and Y4 receptors (IC50s = 2,765, 7,187, and 5,637 nM, respectively). It inhibits NPY-induced increases in BT-549 cell growth and MDA-MB-231 cell migration when used at a...

Velneperit is a nonpeptide antagonist of neuropeptide Y (NPY) receptor Y5 (Ki = 5.3 nM). It is selective for Y5 over Y1, Y2, and Y4 receptors, as well as a panel of 44 receptors, ion channels, transporters and enzymes, at 10 µM. Velneperit inhibits NPY-induced decreases in forskolin-induced cAMP production in CHO-K1...

[cPP1-7,NPY19-23,Ala31,Aib32,Gln34] - Pancreatic polypeptide is an agonist of the neuropeptide Y (NPY) receptor Y5. It inhibits cAMP production induced by forskolin (Cay-11018) in HEK293 cells expressing the human Y5 receptor (EC50 = 17 nM). [cPP1-7,NPY19-23,Ala31,Aib32,Gln34] - Pancreatic polypeptide selectively...