Cercosporamide

Cercosporamide
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay15500-500 500 µg -

6 - 10 business days*

262.00€
Cay15500-2.5 2500 µg -

6 - 10 business days*

1,239.00€
 
Cercosporamide is a natural antifungal phytotoxin isolated from the Cercosporidium fungus, which... more
Product information "Cercosporamide"
Cercosporamide is a natural antifungal phytotoxin isolated from the Cercosporidium fungus, which infects the leaves of cassava plants. Its antifungal effect results from its selective and potent inhibition of fungal PKC-like 1 kinases (Pkc1), which are central to cell wall integrity (IC50 = 25 nM for Candida Pkc1). Cercosporamide less effectively inhibits human PKC isoforms PKCalpha, beta, and gamma (IC50s = 1.02, 0.35, and 5.8 µM, respectively), an action linked to lowering of plasma glucose in hyperglycemic mice. However, it potently inhibits MAPK-interacting kinases Mnk1 and Mnk2 (IC50 = 115 and 11 nM, respectively), reducing protein translation in cancer cells. Cercosporamide is orally bioavailable.Formal Name: (9aS)-8-acetyl-9,9a-dihydro-1,3,7-trihydroxy-9a-methyl-9-oxo-4-dibenzofurancarboxamide. CAS Number: 131436-22-1. Molecular Formula: C16H13NO7. Formula Weight: 331.3. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMF: Soluble, DMSO: Soluble, Ethanol: Soluble, Methanol: Soluble. SMILES: OC1=CC(O)=C(C(N)=O)C(O2)=C1[C@@]3(C)C2=CC(O)=C(C(C)=O)C3=O. InChi Code: InChI=1S/C16H13NO7/c1-5(18)10-7(20)4-9-16(2,14(10)22)12-8(21)3-6(19)11(15(17)23)13(12)24-9/h3-4,19-21H,1-2H3,(H2,17,23)/t16-/m1/s1. InChi Key: GEWLYFZWVLXQME-MRXNPFEDSA-N. Origin: Fungus/Cercosporidium sp..
Keywords: (9aS)-8-acetyl-9,9a-dihydro-1,3,7-trihydroxy-9a-methyl-9-oxo-4-dibenzofurancarboxamide
Supplier: Cayman Chemical
Supplier-Nr: 15500

Properties

Application: Fungal Pkc1 inhibitor
MW: 331.3 D
Formula: C16H13NO7
Purity: >95%
Format: Solid

Database Information

CAS : 131436-22-1| Matching products
KEGG ID : K02677 | Matching products

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: -20°C)
Signal Word: Warning
GHS Hazard Pictograms:
H Phrases: H302
P Phrases: P264, P270, P330, P301+P310, P501
Caution
Our products are for laboratory research use only: Not for administration to humans!
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