Cefamandole Nafate

Cefamandole nafate is a formate ester prodrug form of the cephalosporin antibiotic cefamandole (Cay-18138). Cefamandole nafate inhibits the growth of E. cloacae, E. coli, K. pneumoniae, P. mirabilis, P. vulgaris, P. morganii, S. aureus, and S. pyogenes in vitro (MICs = 0.1-50 µg/ml). In vivo, cefamanadole nafate protects against E. cloacae, E. coli, K. pneumoniae, P. mirabilis, P. vulgaris, P. morganii, S. aureus, and S. pyogenes infection in mice (ED50s = 0.3-334 mg/kg). Cefamandole (500 mg/kg) also protects against nephrotoxicity induced by the aminoglycoside antibiotic tobramycin (Cay-14596) in rats.Formal Name: (6R,7R)-7-[[(2R)-2-(formyloxy)-2-phenylacetyl]amino]-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, monosodium salt. CAS Number: 42540-40-9. Synonyms: NSC 299588. Molecular Formula: C19H17N6O6S2 . Na. Formula Weight: 512.5. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, PBS (pH 7.2): 10 mg/ml. lambdamax: 272 nm. SMILES: O=C(N[C@@H]1C(N2[C@]1([H])SCC(CSC3=NN=NN3C)=C2C([O-])=O)=O)[C@H](OC=O)C4=CC=CC=C4.[Na+]. InChi Code: InChI=1S/C19H18N6O6S2.Na/c1-24-19(21-22-23-24)33-8-11-7-32-17-12(16(28)25(17)13(11)18(29)30)20-15(27)14(31-9-26)10-5-3-2-4-6-10,/h2-6,9,12,14,17H,7-8H2,1H3,(H,20,27)(H,29,30),/q,+1/p-1/t12-,14-,17-,/m1./s1. InChi Key: ICZOIXFFVKYXOM-YCLOEFEOSA-M.