Description: Cefamandole nafate (Cephamandole nafate) is a second-generation broad-spectrum cephalosporin antibiotic. Target: Antibiotic, Antibacterial. Smiles: [Na+].CN1N=NN=C1SCC1=C(N2[C@H](SC1)[C@H](NC(=O)[C@H](OC=O)C1=CC=CC=C1)C2=O)C([O-])=O. References: Taha, M., et al.: Bioorg. Med. Chem., 16, 1218 (2008)

Cefamandole nafate is a formate ester prodrug form of the cephalosporin antibiotic cefamandole (Cay-18138). Cefamandole nafate inhibits the growth of E. cloacae, E. coli, K. pneumoniae, P. mirabilis, P. vulgaris, P. morganii, S. aureus, and S. pyogenes in vitro (MICs = 0.1-50 µg/ml). In vivo, cefamanadole nafate...