Cdk12-IN-2
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Cdk12-IN-2 is an inhibitor of Cdk12 and Cdk13 (IC50s = 0.052 and 0.01 µM, respectively). It is... more
Product information "Cdk12-IN-2"
Cdk12-IN-2 is an inhibitor of Cdk12 and Cdk13 (IC50s = 0.052 and 0.01 µM, respectively). It is selective for Cdk12 over Cdk2, -7, -8, and -9 (IC50s = >100, >10, >10, and 16 µM, respectively). Cdk12-IN-2 inhibits RNA polymerase II phosphorylation in SK-BR-3 cells (IC50 = 0.195 µM). SMILES O=C(NCC1=CC=CC=C1)N([C@@H]2CC[C@H](CC2)NC3=CC=C(C#N)C=N3)C(C=C4)=CC=C4C(C=C5)=CN(C)C5=O InChi Code InChI=1S/C32H32N6O2/c1-37-22-26(10-18-31(37)39)25-8-13-28(14-9-25)38(32(40)35-20-23-5-3-2-4-6-23)29-15-11-27(12-16-29)36-30-17-7-24(19-33)21-34-30/h2-10,13-14,17-18,21-22,27,29H,11-12,15-16,20H2,1H3,(H,34,36)(H,35,40)/t27-,29- InChi Key HDJBGURZVALLMD-KWQFAZJVSA-N
| Keywords: | Cdk12 Inhibitor 2, Cyclin-dependent Kinase 12 Inhibitor 2, Cyclin-dependent Kinase 12-IN-2, N-[trans-4-[(5-cyano-2-pyridinyl)amino]cyclohexyl]-N-[4-(1,6- dihydro-1-methyl-6-oxo-3-pyridinyl)phenyl]-N'-(phenylmethyl)-urea |
| Supplier: | Cayman Chemical |
| Supplier-Nr: | 43703 |
Properties
| Application: | Cdk12 / Cdk13 inhibitor |
| MW: | 532.65 D |
| Formula: | C32H32N6O2 |
| Purity: | >98% |
| Format: | Solid |
Database Information
| CAS : | 2244987-03-7| Matching products |
| KEGG ID : | K08819 | Matching products |
Handling & Safety
| Storage: | -20°C |
| Shipping: | +20°C (International: -20°C) |
| Signal Word: | Warning |
| GHS Hazard Pictograms: |
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| H Phrases: | H315, H319, H335 |
| P Phrases: | P261, P264, P271, P280, P302+352, P304+340, P305+351+338, P312, P321, P332+313, P337+313, P362+364, P403+233, P405, P501 |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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