CCT251236

CCT251236 is an inhibitor of transcription mediated by heat shock factor 1 (Hsf1) that binds to Pirin (Ki = 28 nM) and inhibits Hsf1-mediated induction of heat shock protein 27 (Hsp27) in U2OS cells (IC50 = 19 nM). It inhibits growth of SKOV3 ovarian carcinoma cells (GI50 = 1.1 nM). CCT251236 (20 mg/kg) reduces tumor volume in an SKOV3 mouse xenograft model.Formal Name: N-[5-[[(2,3-dihydro-1,4-benzodioxin-6-yl)carbonyl]amino]-2-methylphenyl]-2-[2-(1-pyrrolidinyl)ethoxy]-6-quinolinecarboxamide. CAS Number: 1693731-40-6. Molecular Formula: C32H32N4O5. Formula Weight: 552.6. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 3mg/mL, DMSO: 3mg/mL, DMSO:PBS (pH 7.2) (1:2): 0.3mg/mL. lambdamax: 244 nm. SMILES: O=C(NC1=CC=C(C)C(NC(C2=CC(C=CC(OCCN3CCCC3)=N4)=C4C=C2)=O)=C1)C(C=C5)=CC6=C5OCCO6. InChi Code: InChI=1S/C32H32N4O5/c1-21-4-8-25(33-31(37)24-6-10-28-29(19-24)40-17-16-39-28)20-27(21)35-32(38)23-5-9-26-22(18-23)7-11-30(34-26)41-15-14-36-12-2-3-13-36/h4-11,18-20H,2-3,12-17H2,1H3,(H,33,37)(H,35,38). InChi Key: KLHOCHQJHXNKAS-UHFFFAOYSA-N.