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Item number: Cay27788-5

CCT251236 is an inhibitor of transcription mediated by heat shock factor 1 (Hsf1) that binds to Pirin (Ki = 28 nM) and inhibits Hsf1-mediated induction of heat shock protein 27 (Hsp27) in U2OS cells (IC50 = 19 nM). It inhibits growth of SKOV3 ovarian carcinoma cells (GI50 = 1.1 nM). CCT251236 (20 mg/kg) reduces...

Keywords:	N-[5-[[(2,3-dihydro-1,4-benzodioxin-6-yl)carbonyl]amino]-2-methylphenyl]-2-[2-(1-pyrrolidinyl)ethoxy]-6-quinolinecarboxamide
Application:	Pirin-binding Hsf1-mediated-transcription inhibitor
CAS	1693731-40-6
MW:	552.6 D

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CCT251236

Item number: TGM-T14905-1mg

Description: CCT251236 is a cell-based phenotypic high-throughput screening (HTS) chemical probe developed to screen for inhibitors of the HSF1 stress pathway.CCT251236 exhibits antimyeloma activity and inhibits HSF1. Target: HSP. Smiles: Cc1ccc(NC(=O)c2ccc3OCCOc3c2)cc1NC(=O)c1ccc2nc(OCCN3CCCC3)ccc2c1. References:...

Application:	Pirin-binding Hsf1-mediated-transcription inhibitor
CAS	1693731-40-6
MW:	552.62 D

32.00€ *

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