CCT077791

CCT077791 is an inhibitor of the histone acetyltransferase p300 (IC50 = 7.3 µM). It is also active against S. aureus, S. epidermidis, and B. subtilis (MICs = 2.5, 0.3, and 2.5 µg/ml, respectively). CCT077791 (10 µM) decreases global protein, histone H3 and H4, and alpha-tubulin acetylation in HCT116 colorectal cancer cells. It inhibits growth of HCT116 cells and HT-29 colon cancer cells (GI50s = 3 and 2.1 µM, respectively). InChI: InChI=1S/C9H5ClN2O3S/c10-8-5-9(13)11(16-8)6-1-3-7(4-2-6)12(14)15/h1-5H InChIKey: RBOAUBASDMUWJM-UHFFFAOYSA-N SMILES: O=C1C=C(SN1C2=CC=C([N+]([O-])=O)C=C2)Cl