138 products were found matching "K04498"!

GNE-781 is an inhibitor of CREB-binding protein (CBP) and histone acetyltransferase p300 (IC50s = 0.94 and 1.2 nM, respectively). It is selective for CBP and p300 over bromodomain-containing protein 4 (BRD4) bromodomain 1, BRD4 bromodomain 2, and bromodomain and PHD finger-containing 1 (BRPF1, IC50s = 5.1, 12, and...

CTB is an activator of the histone acetyltransferase p300. It induces acetylation of core histones in HeLa cells when used at a concentration of 200 µM. CTB (85.43 µM) increases p53 acetylation and induces apoptosis in MCF-7 cells.Formal Name: N-[4-chloro-3-(trifluoromethyl)phenyl]-2-ethoxy-benzamide. CAS Number:...

JQAD1 is a proteolysis-targeting chimera (PROTAC) composed of the p300 and CREB-binding protein (CBP) inhibitor A-485 (Cay-24119) conjugated to a cereblon (CRBN) ligand. It selectively induces the degradation of p300 over CBP in Kelly MYCN-amplified neuroblastoma cells when used at a concentration of 10 µM for 24...

The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Mouse EP300. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Mouse EP300. Next,...

The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human EP300. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human EP300. Next,...

The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human CREBBP. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human CREBBP....

C646 is an inhibitor of the histone acetyltransferase p300 (IC50 = 1.6 µM). It competitively (versus acetyl-CoA) binds p300 (Ki = 400 nM) and does not inhibit several other acetyltransferases. The action of C646 appears to be irreversible through covalent modification of the enzyme target. It blocks the growth of...

A-485 is an inhibitor of the histone acetyltransferase p300/CBP (IC50 = 60 nM). It decreases acetylated histone H3 lysine 27 (H3K27Ac), but not H3K9Ac, levels in PC3 cells in a concentration-dependent manner. A-485 reduces proliferation of non-small cell lung cancer (NSCLC), small cell lung cancer, triple-negative...

cAMP-responsive element-binding protein binding protein (CREBBP) and E1A-associated protein p300 (EP300) are transcriptional co-activators. Each contains a bromodomain, which recognizes acetylated lysine residues on target proteins. SGC-CBP30 is a potent inhibitor of CREBBP and EP300 bromodomains (IC50s = 21-69 and...

Protein function: Functions as histone acetyltransferase and regulates transcription via chromatin remodeling (PubMed:23415232, PubMed:23934153, PubMed:8945521). Acetylates all four core histones in nucleosomes. Histone acetylation gives an epigenetic tag for transcriptional activation (PubMed:23415232,...

Human E1A binding protein p300, also known as EP300, KAT3B, or RSTS2, GenBank Accession No. NM_001429, a.a. 965-1810, with N-terminal His-GST-tag, MW=125 kDa, expressed in Sf9 cells via a baculovirus expression system. Specific Activity: 4430 pmole/min/µg.

Protein function: Acetylates histones, giving a specific tag for transcriptional activation. Also acetylates non-histone proteins, like NCOA3 and FOXO1. Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1. Acts as a circadian...