179 products were found matching "K04498"!

CREB-binding protein (CREBBP/CBP), encoded by the human CREBBP gene, is a transcriptional co-activator. CREBBP functions through interactions with transcription factors, mediated by one or more domains: the nuclear receptor interaction domain (RID), the KIX domain (CREB and MYB interaction domain), the...

CCT077791 is an inhibitor of the histone acetyltransferase p300 (IC50 = 7.3 µM). It is also active against S. aureus, S. epidermidis, and B. subtilis (MICs = 2.5, 0.3, and 2.5 µg/ml, respectively). CCT077791 (10 µM) decreases global protein, histone H3 and H4, and alpha-tubulin acetylation in HCT116 colorectal...

DS9300 is an inhibitor of histone acetyltransferase p300 (IC50 = 28 nM). It inhibits acetylation of lysine 27 on histone H3 (H3K27) in LK-2 cells (IC50 = 54 nM). DS9300 inhibits the growth of VCaP prostate cancer cells (GI50 = 0.6 nM). In vivo, DS9300 (0.3-3 mg/kg) reduces tumor volume in a VCaP castrated mouse...

C646 is an inhibitor of the histone acetyltransferase p300 (IC50 = 1.6 µM). It competitively (versus acetyl-CoA) binds p300 (Ki = 400 nM) and does not inhibit several other acetyltransferases. The action of C646 appears to be irreversible through covalent modification of the enzyme target. It blocks the growth of...

A-485 is an inhibitor of the histone acetyltransferase p300/CBP (IC50 = 60 nM). It decreases acetylated histone H3 lysine 27 (H3K27Ac), but not H3K9Ac, levels in PC3 cells in a concentration-dependent manner. A-485 reduces proliferation of non-small cell lung cancer (NSCLC), small cell lung cancer, triple-negative...

cAMP-responsive element-binding protein binding protein (CREBBP) and E1A-associated protein p300 (EP300) are transcriptional co-activators. Each contains a bromodomain, which recognizes acetylated lysine residues on target proteins. SGC-CBP30 is a potent inhibitor of CREBBP and EP300 bromodomains (IC50s = 21-69 and...

Protein function: Functions as histone acetyltransferase and regulates transcription via chromatin remodeling (PubMed:23415232, PubMed:23934153, PubMed:8945521). Acetylates all four core histones in nucleosomes. Histone acetylation gives an epigenetic tag for transcriptional activation (PubMed:23415232,...

Human E1A binding protein p300, also known as EP300, KAT3B, or RSTS2, GenBank Accession No. NM_001429, a.a. 965-1810, with N-terminal His-GST-tag, MW=125 kDa, expressed in Sf9 cells via a baculovirus expression system. Specific Activity: 4430 pmole/min/µg.

Protein function: Acetylates histones, giving a specific tag for transcriptional activation. Also acetylates non-histone proteins, like NCOA3 and FOXO1. Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1. Acts as a circadian...

I-CBP112 is an inhibitor of p300 and CREB-binding protein (CBP) histone acetyltransferases. It binds to the p300 and CBP bromodomains (Kds = 167 and 151 nM, respectively) and is selective for p300 and CBP over BRD4, as well as a panel of 104 nuclear receptors and ion channels and a panel of 32 enzymes at 10 µM....

HAT Inhibitor II is a cell-permeable, selective inhibitor of the histone acetyltransferase p300 (IC50 = 5 µM). It does not inhibit PCAF or GCN5 acetyltransferases.Formal Name: 2,6-bis[(3-bromo-4-hydroxyphenyl)methylene]-cyclohexanone. CAS Number: 932749-62-7. Synonyms: Histone Acetyltransferase Inhibitor II....

Protein function: Acetylates histones, giving a specific tag for transcriptional activation. Also acetylates non-histone proteins, like NCOA3 and FOXO1. Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1. Acts as a circadian...