CCG-203971
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Description: CCG-203971 is an inhibitor of SRE activation in the prostate cancer cell line PC-3... more
Product information "CCG-203971"
Description: CCG-203971 is an inhibitor of SRE activation in the prostate cancer cell line PC-3 (IC50: 6.4 µM), with 87% inhibition of SRE activation achieved at 100 µM. This compound also inhibits PC-3 cell migration (IC50: 4.2 µM), as determined by a scratch wound assay. CCG-203971(CCG203971) causes no cytotoxicity when evaluated by the WST-1 assay. It is well tolerated in normal mice up to doses of 100 mg/kg given intraperitoneally over five days. Target: Ras, Rho. Smiles: Clc1ccc(NC(=O)C2CCCN(C2)C(=O)c2cccc(c2)-c2ccco2)cc1. References: Haak AJ, et al. Targeting the myofibroblast genetic switch: inhibitors of myocardin-related transcription factor/serum response factor-regulated gene transcription prevent fibrosis in a murine model of skin injury. J Pharmacol Exp Ther. 2014 Jun,349(3):480-6.
| Keywords: | CCG203971 |
| Supplier: | TargetMol |
| Supplier-Nr: | T4306 |
Properties
| Application: | SRE activation inhibitor |
| MW: | 408.88 D |
| Formula: | C23H21ClN2O3 |
Database Information
| CAS : | 1443437-74-8| Matching products |
| KEGG ID : | K04378 | Matching products |
Handling & Safety
| Storage: | -20°C |
| Shipping: | +4°C (International: +4°C) |
| Signal Word: | Warning |
| GHS Hazard Pictograms: |
|
| H Phrases: | H302 |
| P Phrases: | P264, P270, P330, P301+P310, P501 |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
You will get a certificate here
Viewed