CAY10566

CAY10566
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay10012562-1 1 mg -

6 - 10 business days*

82.00€
Cay10012562-5 5 mg -

6 - 10 business days*

345.00€
Cay10012562-10 10 mg -

6 - 10 business days*

610.00€
Cay10012562-25 25 mg -

6 - 10 business days*

1,219.00€
 
Stearoyl-CoA desaturase (SCD) catalyzes the committed step of the conversion of saturated,... more
Product information "CAY10566"
Stearoyl-CoA desaturase (SCD) catalyzes the committed step of the conversion of saturated, long-chain fatty acids to monounsaturated fatty acids. The SCD1 gene is thought to play a key role in lipid homeostasis and body weight regulation. Thus, modulating SCD1 activity pharmacologically may be a useful tool for regulating type 2 diabetes, dyslipidemia, and obesity. CAY10566 is a potent and selective inhibitor of SCD1 that demonstrates IC50 values of 4.5 and 26 nM in mouse and human enzymatic assays, respectively. This compound inhibits the conversion of saturated, long-chain fatty acyl-CoAs to monounsaturated, long-chain fatty acyl-CoAs in HepG2 cells with IC50 values of 7.9 and 6.8 nM, respectively, when heptadecanoic acid and palmitic acid are used as the substrate. Formal Name: 3-[4-(2-chloro-5-fluorophenoxy)-1-piperidinyl]-6-(5-methyl-1,3,4-oxadiazol-2-yl)-pyridazine. CAS Number: 944808-88-2. Molecular Formula: C18H17ClFN5O2. Formula Weight: 389.8. Purity: >98%. Formulation: A crystalline solid. Solubility: DMF: 20 mg/ml, DMF:PBS (pH 7.2) (1:5): 0.15 mg/ml, DMSO: 10 mg/ml, Ethanol: 0.15 mg/ml. SMILES: Cc1nnc(o1)c1ccc(nn1)N1CCC(CC1)Oc1cc(F)ccc1Cl. InChi Code: InChI=1S/C18H17ClFN5O2/c1-11-21-24-18(26-11)15-4-5-17(23-22-15)25-8-6-13(7-9-25)27-16-10-12(20)2-3-14(16)19/h2-5,10,13H,6-9H2,1H3. InChi Key: WFOFPVXMPTVOTJ-UHFFFAOYSA-N.
Keywords: 3-[4-(2-chloro-5-fluorophenoxy)-1-piperidinyl]-6-(5-methyl-1,3,4-oxadiazol-2-yl)-pyridazine
Supplier: Cayman Chemical
Supplier-Nr: 10012562

Properties

Application: SCD inhibitor
MW: 389.8 D
Formula: C18H17ClFN5O2
Purity: >98%
Format: Crystalline Solid

Database Information

CAS : 944808-88-2| Find alternatives
KEGG ID : K00507 | Find alternatives

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: -20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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