Carbenoxolone (sodium salt)

Carbenoxolone is a derivative of beta-glycyrrhetinic acid (Cay-11845), a major metabolite of glycyrrhizin, one of the main constituents of licorice. Similar to beta-glycyrrhetinic acid and glycyrrhizin, carbenoxolone has been shown to exhibit anti-ulcerative and anti-inflammatory properties. Carbenoxolone inhibits 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1, Cay-10007815) conversion of cortisol to cortisone, which contributes to its potential to induce mineralocorticoid hypertension. It is also reported to inhibit 11beta-HSD2 conversion of cortisone to cortisol resulting in improved cognitive and neuroprotective effects.Formal Name: (3beta,20beta)-3-(3-carboxy-1-oxopropoxy)-11-oxo-olean-12-en-29-oic acid, disodium salt. CAS Number: 7421-40-1. Molecular Formula: C34H48O7 . 2Na. Formula Weight: 614.7. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: Ethanol: 10 mg/ml, PBS (pH 7.2): 1 mg/ml. lambdamax: 250 nm. SMILES: [O-]C([C@@]1(C)CC[C@]([C@@]2([H])C1)(C)CC[C@@](C2=C3)(C)[C@]4(C)CC[C@@]5([H])C(C)(C)[C@@H](OC(CCC([O-])=O)=O)CC[C@]5(C)[C@@]4([H])C3=O)=O.[Na+].[Na+]. InChi Code: InChI=1S/C34H50O7.2Na/c1-29(2)23-10-13-34(7)27(32(23,5)12-11-24(29)41-26(38)9-8-25(36)37)22(35)18-20-21-19-31(4,28(39)40)15-14-30(21,3)16-17-33(20,34)6,,/h18,21,23-24,27H,8-17,19H2,1-7H3,(H,36,37)(H,39,40),,/q,2*+1/p-2/t21-,23-,24-,27+,30+,31-,32-,33. InChi Key: BQENDLAVTKRQMS-SBBGFIFASA-L.