75 products were found matching "K15680"!

An 11beta-HSD1 inhibitor (IC50s = 2.9 and 1.6 nM for the human and mouse enzymes, respectively), reduces postprandial blood glucose, HbA1c, blood LDL and total cholesterol, and blood triglyceride levels in an ob/ob mouse model of type 2 diabetes and metabolic syndrome at 20 mg/kg orally. SMILES:...

An 11beta-HSD1 inhibitor (IC50 = 9 nM for the human enzyme), selective for 11beta-HSD1 over 11beta-HSD2 and 17beta-HSD1 (IC50s = >30 µM for both), and over 17beta-HSD3 with less than 5% inhibition at 10 µM, prevents impairments in cardiac function in a minipig model of myocardial infarction at 50 mg/kg per day,...

INCB 13739 is an inhibitor of 11beta-hydroxysteroid dehydrogenase 1 (11beta-HSD1, IC50 = 3.2 nM). It is greater than 1,000-fold selective for 11beta-HSD1 over 11beta-HSD2, the mineralocorticoid receptor, and the glucocorticoid receptor at 5 µM. INCB 13739 inhibits 11beta-HSD1 activity in peripheral blood mononuclear...

Carbenoxolone is a derivative of beta-glycyrrhetinic acid (Cay-11845), a major metabolite of glycyrrhizin, one of the main constituents of licorice. Similar to beta-glycyrrhetinic acid and glycyrrhizin, carbenoxolone has been shown to exhibit anti-ulcerative and anti-inflammatory properties. Carbenoxolone inhibits...

A synthetic derivative of glycyrrhetinic acid

BVT 2733 is an inhibitor of 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1, Cay-10007815). In a mouse model of hyperglycemia and hyperinsulinemia, BVT 2733 (100 mg/kg) inhibits 11beta-HSD1 activity in isolated liver and decreases blood glucose and insulin concentrations. It decreases the expression of...

Protein function: Catalyzes reversibly the conversion of cortisol to the inactive metabolite cortisone. Catalyzes reversibly the conversion of 7-ketocholesterol to 7-beta-hydroxycholesterol. In intact cells, the reaction runs only in one direction, from 7- ketocholesterol to 7-beta-hydroxycholesterol. [The UniProt...

0.5mg/ml if reconstituted with 0.2ml sterile DI water. 11-beta-hydroxysteroid dehydrogenase type 1 is an NADPH-dependent enzyme highly expressed in key metabolic tissues including liver, adipose tissue, and the central nervous system. In these tissues, HSD11B1 reduces cortisone to the active hormone cortisol that...

0.5 mg/ml in 1X TBS, pH7.3, with 0.5% BSA (US sourced) and 0.02% sodium azide. Additional name(s) for this target protein: 11-beta-hydroxysteroid dehydrogenase 1 Protein function: Catalyzes reversibly the conversion of cortisol to the inactive metabolite cortisone (PubMed:10497248). Catalyzes reversibly the...

0.5 mg/ml in 1X TBS, pH7.3, with 0.5% BSA (US sourced) and 0.02% sodium azide. Additional name(s) for this target protein: Hydroxysteroid (11-beta) dehydrogenase 1 Protein function: Catalyzes reversibly the conversion of cortisol to the inactive metabolite cortisone. [The UniProt Consortium]

The protein encoded by this gene is a microsomal enzyme that catalyzes the conversion of the stress hormone cortisol to the inactive metabolite cortisone. In addition, the encoded protein can catalyze the reverse reaction, the conversion of cortisone to cortisol. Too much cortisol can lead to central obesity, and a...