Calcitriol-d6

Calcitriol-d6 is intended for use as an internal standard for the quantification of calcitriol (Cay-71820) by GC- or LC-MS. Calcitriol is a vitamin D3 receptor agonist and an active metabolite of vitamin D3 (Cay-11792). It is formed via a multi-step process, in which vitamin D3 undergoes hydroxylation to 25-hydroxy vitamin D3 (Cay-9000683) in the liver, followed by further hydroxylation at the 1alpha-position in the kidney. Calcitriol binds to the vitamin D3 receptor (Kd = 16 pM) and induces differentiation of U937 acute monocytic leukemia cells (EC50 = 2,000 pM). It induces cell cycle arrest at the S phase and apoptosis in primary adenomatous and hyperplastic human parathyroid cells when used at a concentration of 10 nM. Calcitriol (0.65 nmol/animal) increases bone calcium mobilization in chicks on a low-calcium diet. It stimulates calcium absorption in the intestines in a chick model of rickets induced by a vitamin D3-deficient diet when administered at a dose of 25 µg/animal. Formulations containing calcitriol have been used in the treatment of hypocalcemia.Formal Name: (1R,3S,5Z)-4-methylene-5-[(2E)-2-[(1R,3aS,7aR)-octahydro-1-[(1R)-5-hydroxy-1-methyl-5-(methyl-d3)hexyl-6,6,6-d3]-7a-methyl-4H-inden-4-ylidene]ethylidene]-1,3-cyclohexanediol. CAS Number: 78782-99-7. Synonyms: 1,25-dihydroxy Cholecalciferol-d6, 1alpha,25-dihydroxy Cholecalciferol-d6, Ro 21-5535/2, 1,25-dihydroxy Vitamin D3-d6, 1alpha,25-dihydroxy Vitamin D3-d6. Molecular Formula: C27H38D6O3. Formula Weight: 422.7. Purity: >99% deuterated forms (d1-d6). Formulation: (Request formulation change), A solid. Solubility: Chloroform: Soluble, DMSO: Soluble. SMILES: C[C@@]12[C@](CC[C@]2([H])[C@H](C)CCCC(C([2H])([2H])[2H])(O)C([2H])([2H])[2H])([H])/C(CCC1)=C/C=C3C[C@@H](O)C[C@H](O)C/3=C. InChi Code: InChI=1S/C27H44O3/c1-18(8-6-14-26(3,4)30)23-12-13-24-20(9-7-15-27(23,24)5)10-11-21-16-22(28)17-25(29)19(21)2/h10-11,18,22-25,28-30H,2,6-9,12-17H2,1,3-5H3/b20-10+,21-11-/t18-,22-,23-,24+,25+,27-/m1/s1/i3D3,4D3. InChi Key: GMRQFYUYWCNGIN-HLEVXKMQSA-N.