C6 Ceramide

Description: C6 Ceramide (N-hexanoylsphingosine) is an activator of the ceramide pathway that arrests cells in the G0/G1 phase by activating ERK. It can act in a variety of cancer cell lines. Target: Apoptosis. Smiles: CCCCCCCCCC CCC\C=C\[C@@H](O)[C@H](CO)NC(=O)CCCCC. References: Zhu Q, et, al. C6-ceramide synergistically potentiates the anti-tumor effects of histone deacetylase inhibitors via AKT dephosphorylation and alpha-tubulin hyperacetylation both in vitro and in vivo. Cell Death Dis. 2011 Jan 27,2(1):e117.