C-7280948

C-7280948 is a protein arginine methyltransferase 1 (PRMT1) inhibitor (IC50 = 12.8 µM, in vitro). PRMT1 enzymes transfer a methyl group from S-adenosylmethionine to arginine residues on histones, which leads to transcription. PRMT1 is essential for mixed lineage leukemia oncogenic transformation and thus its inhibition is a potential treatment for these aggressive leukemias.Formal Name: 4-amino-N-(2-phenylethyl)-benzenesulfonamide. CAS Number: 587850-67-7. Molecular Formula: C14H16N2O2S. Formula Weight: 276.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 25 mg/ml, DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml, DMSO: 20 mg/ml, Ethanol: 1 mg/ml. lambdamax: 265 nm. SMILES: O=S(NCCC1=CC=CC=C1)(C2=CC=C(N)C=C2)=O. InChi Code: InChI=1S/C14H16N2O2S/c15-13-6-8-14(9-7-13)19(17,18)16-11-10-12-4-2-1-3-5-12/h1-9,16H,10-11,15H2. InChi Key: BYWZPUPRVIECEC-UHFFFAOYSA-N.