BX-513 (hydrochloride)

BX-513 is an antagonist of chemokine (C-C motif) receptor 1 (CCR1, Ki = 0. µM). It is selective for CCR1 over 15 other receptors (Kis = 2->10 µM). BX-513 inhibits increases in acidification induced by chemokine (C-C motif) ligand 18 (CCL18) in THP-1 monocytes in a concentration-dependent manner. It inhibits RANTES- and CCL18-induced chemotaxis in isolated peripheral blood mononuclear cells (PBMCs) when used at concentrations of 10 or 100 nM.. Solulibility: DMSO: Sparingly soluble: 1-10 mg/ml: Ethanol: Slightly soluble: 0.1-1 mg/ml.