Butein

Butein is a plant polyphenol that is classified as a chalcone, due to the propenone linkage between the phenol groups. Like other polyphenols, butein is a potent antioxidant and affects the numerous pathways modulated by oxidant tone, including inflammation, cancer, and immune response. It inhibits 5-lipoxygenase, the enoyl-acyl-carrier protein reductase of P. falciparum, angiotensin-converting enzyme, and Src kinase (IC50 or Ki values of 0.01, 2.97, 0.73, and 65 µM, respectively). Butein is also a sirtuin activator, increasing trichostatin A (Cay-89730)-insensitive deacetylase activity.Formal Name: (2E)-1-(2,4-dihydroxyphenyl)-3-(3,4-dihydroxyphenyl)-2-propen-1-one. CAS Number: 487-52-5. Synonyms: 2',3,4,4'-tetrahydroxy Chalcone. Molecular Formula: C15H12O5. Formula Weight: 272.3. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 25 mg/ml, DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml, DMSO: 20 mg/ml, Ethanol: 20 mg/ml. lambdamax: 262, 348, 382 nm. SMILES: OC1=C(O)C=CC(/C=C/C(C2=C(O)C=C(O)C=C2)=O)=C1. InChi Code: InChI=1S/C15H12O5/c16-10-3-4-11(14(19)8-10)12(17)5-1-9-2-6-13(18)15(20)7-9/h1-8,16,18-20H/b5-1+. InChi Key: AYMYWHCQALZEGT-ORCRQEGFSA-N.