BRM/BRG1 ATP Inhibitor 1

BRM/BRG1 ATP inhibitor 1 is an allosteric dual inhibitor of brahma homologue (BRM), also known as SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin, subfamily A, member 2 (SMARCA2), and brahma-related gene 1 (BRG1), also known as SMARCA4, ATPase activities (IC50s = <0.005 µM for both). It reduces the expression of keratin 80 (KRT80) in H1299 and RERF-LC-A1 cells. BRM (20mg/kg) reduces tumor growth in a RERF-LC-A1 lung cancer mouse xenograft model.Formal Name: N-[3-(difluoromethyl)-5-isothiazolyl]-N'-[2-fluoro-5-(hydroxymethyl)-4-pyridinyl]-urea. CAS Number: 2270879-17-7. Synonyms: Brahma Homologue/Brahma-related Gene 1 Adenosine 5'-triphosphate Inhibitor 1. Molecular Formula: C11H9F3N4O2S. Formula Weight: 318.3. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: Soluble. lambdamax: 276 nm. SMILES: O=C(NC1=CC(F)=NC=C1CO)NC2=CC(C(F)F)=NS2. InChi Code: InChI=1S/C11H9F3N4O2S/c12-8-1-6(5(4-19)3-15-8)16-11(20)17-9-2-7(10(13)14)18-21-9/h1-3,10,19H,4H2,(H2,15,16,17,20). InChi Key: CKYCAIAVJIFWPE-UHFFFAOYSA-N.