Bosentan
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You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Description: Bosentan (Benzenesulfonamide) is a sulfonamide-derived, competitive and specific... more
Product information "Bosentan"
Description: Bosentan (Benzenesulfonamide) is a sulfonamide-derived, competitive and specific endothelin receptor antagonist with a slightly higher affinity for the endothelin A receptor than endothelin B receptor. Bosentan blocks the action of endothelin 1, an extremely potent endogenous vasoconstrictor and bronchoconstrictor, by binding to endothelin A and endothelin B receptors in the endothelium and vascular smooth muscle. Bosentan decreases both pulmonary and systemic vascular resistance and is particularly used in the treatment of pulmonary arterial hypertension. Target: Endothelin Receptor. Smiles: COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(cc2)C(C)(C)C)nc(nc1OCCO)-c1ncccn1. References: Dhillon S, et al. Am J Cardiovasc Drugs,2009,9(5):331-50.
| Keywords: | Actelion, Benzenesulfonamide, Ro 47-0203 |
| Supplier: | TargetMol |
| Supplier-Nr: | T6264 |
Properties
| Application: | Antihypertensive, Endothelin receptor antagonist |
| MW: | 551.614 D |
| Formula: | C27H29N5O6S |
Database Information
| CAS : | 147536-97-8| Matching products |
Handling & Safety
| Storage: | -20°C |
| Shipping: | +4°C (International: +4°C) |
| Signal Word: | Warning |
| GHS Hazard Pictograms: |
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| H Phrases: | H361, H412 |
| P Phrases: | P201, P202, P273, P280, P308+313, P405, P501 |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
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