BMS 794833

BMS 794833 is an inhibitor of c-Met and VEGF receptor 2 (VEGFR2) with IC50 values of 1.7 and 15 nM, respectively, that also inhibits Axl, Flt3, and Ron. It inhibits proliferation of GTL-16 gastric carcinoma cells (IC50 = 39 nM) and induces tumor statsis in GTL-16 and U87 mouse xenograft models when administered at a dose of 25 mg/kg.Formal Name: N-[4-[(2-amino-3-chloro-4-pyridinyl)oxy]-3-fluorophenyl]-5-(4-fluorophenyl)-1,4-dihydro-4-oxo-3-pyridinecarboxamide. CAS Number: 1174046-72-0. Molecular Formula: C23H15ClF2N4O3. Formula Weight: 468.8. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 17 mg/ml, DMSO: 17 mg/ml. lambdamax: 298 nm. SMILES: FC1=C(OC2=C(Cl)C(N)=NC=C2)C=CC(NC(C3=CNC=C(C4=CC=C(F)C=C4)C3=O)=O)=C1. InChi Code: InChI=1S/C23H15ClF2N4O3/c24-20-19(7-8-29-22(20)27)33-18-6-5-14(9-17(18)26)30-23(32)16-11-28-10-15(21(16)31)12-1-3-13(25)4-2-12/h1-11H,(H2,27,29)(H,28,31)(H,30,32). InChi Key: PDYXPCKITKHFOZ-UHFFFAOYSA-N.