BMS 191011

BMS 191011 is an activator of large-conductance calcium-activated potassium (KCa1.1/BK) channels that increases maximum potassium current to 126% of control in X. laevis oocytes expressing human KCa1.1 channels when used at a concentration of 1 µM. In vivo, BMS 191011 (10-100 µg/kg, i.v.) increases the diameter of retinal arterioles without affecting blood pressure or heart rate in rats, an effect that is reversed by the KCa1.1 channel blocker iberiotoxin (Cay-14608).Formal Name: 3-[(5-chloro-2-hydroxyphenyl)methyl]-5-[4-(trifluoromethyl)phenyl]-1,3,4-oxadiazol-2(3H)-one. CAS Number: 202821-81-6. Molecular Formula: C16H10ClF3N2O3. Formula Weight: 370.7. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 10 mg/ml, DMSO: 10 mg/ml, DMSO:PBS (pH 7.2) (1:1): 0.3 mg/ml, Ethanol: 3 mg/ml. lambdamax: 280 nm. SMILES: O=C1OC(C2=CC=C(C(F)(F)F)C=C2)=NN1CC3=C(O)C=CC(Cl)=C3. InChi Code: InChI=1S/C16H10ClF3N2O3/c17-12-5-6-13(23)10(7-12)8-22-15(24)25-14(21-22)9-1-3-11(4-2-9)16(18,19)20/h1-7,23H,8H2. InChi Key: QKOWACXSXTXRKA-UHFFFAOYSA-N.