Blarcamesine

Blarcamesine is an agonist of the sigma non-opioid intracellular receptor 1 (sigma1 receptor). It inhibits reductions in mitochondrial oxygen consumption and lipid peroxidation induced by amyloid-beta (Abeta) (25-35) (Abeta (25-35)) in isolated mouse hippocampus when administered at a dose of 1 mg/kg. Blarcamesine (1 mg/kg) improves deficits in novel object recognition induced by Abeta (25-35) in mice, as well as reduces tau phosphorylation and Abeta (1-42) levels in the hippocampus in the same model. It increases the latency to fall in the rotarod test, reduces gait impairments, and reduces increases in the mean acoustic startle response in an Mecp2-/- mouse model of Rett syndrome, an X-linked neurodevelopmental disorder, when administered at a dose of 30 mg/kg per day.Formal Name: tetrahydro-N,N-dimethyl-2,2-diphenyl-3-furanmethanamine. CAS Number: 195615-83-9. Synonyms: AE37, AV2-73. Molecular Formula: C19H23NO. Formula Weight: 281.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: Slightly soluble, Ethanol: 30 mg/ml. SMILES: CN(C)CC1CCOC1(C2=CC=CC=C2)C3=CC=CC=C3. InChi Code: InChI=1S/C19H23NO/c1-20(2)15-18-13-14-21-19(18,16-9-5-3-6-10-16)17-11-7-4-8-12-17/h3-12,18H,13-15H2,1-2H3. InChi Key: BOTHKNZTGGXFEQ-UHFFFAOYSA-N.