46 products were found matching "K20719"!

Description: Blarcamesine (AVex-73) is a muscarinic M1 agonist potentially for the treatment of Alzheimer's disease. Target: AChR. Smiles: C(N(C)C)C1C(OCC1)(C2=CC=CC=C2)C3=CC=CC=C3. References: Matsueda, Gao S , Efferson H , et al. N-terminally LRMK-linked HER-2 peptides, AE-37[J]. 2009.

S1RA is a sigma-1 (sigma1) receptor antagonist (Ki = 17 nM). It is selective for sigma1 receptors over sigma2 receptors (Ki = 9,300 nM), as well as a panel of 170 additional receptors at 1 µM. S1RA reduces capsaicin-induced mechanical allodynia, formalin-induced licking and biting behavior, and partial sciatic nerve...

Pridopidine is a ligand of sigma non-opioid intracellular receptor 1 (sigma1 receptor) and a dopaminergic stabilizer. It binds to the sigma1 receptor and dopamine D2 receptor in the high-affinity state (Kis = 81.3 and 7,521 nM, respectively). Pridopidine (100 µmol/kg) increases striatal 3,4-dihydroxyphenylacetic...

BD 1047 is a selective antagonist of sigma-1 (sigma1) receptors (Ki = 0.9 nM in a radioligand binding assay). It is selective for sigma1 receptors with binding affinity values greater than 10,000 nM for human recombinant dopamine, opioid, PCP, and serotonin receptors in vitro. In vivo, pretreatment with BD 1047...

BD 1063 is an antagonist of sigma-1 (sigma1) receptors (Ki = 9 nM). It is selective for sigma1 receptors over sigma2 (Ki = 449 nM) and serotonin 5-HT2 receptors (Ki = 2,552 nM), as well as opioid, dopamine D2, PCP, serotonin 5-HT1, alpha1-, alpha2-, and beta-adrenergic receptors where it has Ki values of greater...

This gene encodes a receptor protein that interacts with a variety of psychotomimetic drugs, including cocaine and amphetamines. The receptor is believed to play an important role in the cellular functions of various tissues associated with the endocrine, immune, and nervous systems. As indicated by its previous...

This gene encodes a receptor protein that interacts with a variety of psychotomimetic drugs, including cocaine and amphetamines. The receptor is believed to play an important role in the cellular functions of various tissues associated with the endocrine, immune, and nervous systems. As indicated by its previous...

Protein function: May function in lipid transport from the endoplasmic reticulum and be involved in a wide array of cellular functions probably through regulation of the biogenesis of lipid microdomains at the plasma membrane. May regulate calcium efflux at the endoplasmic reticulum. [The UniProt Consortium]

SA 4503 is a sigma-1 (sigma1) receptor agonist that is selective for sigma1 over sigma2 receptors in a radioligand binding assay using guinea pig brain homogenates (Kis = 4.6 and 63 nM, respectively). SA 4503 (10 µM) reduces light-induced cell death, decreases in sigma1 expression, disruption of the mitochondrial...

Reduced haloperidol is an active metabolite of haloperidol (Cay-12014). It is formed via reduction of haloperidol by ketone reductase. Reduced haloperidol inhibits radioligand binding to sigma-1 and dopamine D2 receptors (Kis = 1.4 and 31 nM, respectively) and stimulates brain-derived neurotrophic factor (BDNF)...

Opipramol is a sigma-1 (sigma1) and sigma2 receptor ligand. It binds to sigma1 and sigma2 receptors in guinea pig brain membrane preparations (IC50s = 7 and 56 nM, respectively). It is selective for sigma1 and sigma2 over histamine H2, dopamine D1, alpha1- and alpha2-adrenergic, and muscarinic M1 receptors (IC50s =...

4-IBP is a sigma-1 (sigma1) receptor ligand (Ki = 1.7 nM). It is selective for sigma1 over sigma2 receptors (Ki = 25.2 nM). It inhibits the growth and migration of PC3 prostate cancer and A549 non-small cell lung cancer (NSCLC) cells, as well as the migration of C32 melanoma and U373 MG glioblastoma cells, when used...