Bisindolylmaleimide VIII acetate

Description: Bisindolylmaleimide VIII acetate (Ro 31-7549 acetate) is a potent and selective PKC inhibitor (IC50: 158 nM for rat brain PKC) with IC50 values of 53, 195, 163, 213, and 175 nM for PKC-alpha, PKC-betaI, PKC-betaII, PKC-gamma, and PKC-epsilon, respectively. Target: PKC, Apoptosis. Smiles: CC(O)=O.Cn1cc(C2=C(C(=O)NC2=O)c2cn(CCCN)c3ccccc23)c2ccccc12. References: Wilkinson SE, et al. Isoenzyme specificity of bisindolylmaleimides, selective inhibitors of protein kinase C. Biochem J. 1993 Sep 1,294 ( Pt 2):335-7.