Bifeprunox (mesylate)

Bifeprunox is an atypical antipsychotic. It is a dopamine D2 receptor partial agonist and an agonist of the serotonin (5-HT) receptor subtype 5-HT1A (Kis = 2.2 and 9.3 nM, respectively). Bifeprunox inhibits apomorphine-induced climbing behavior in mice (ED50 = 0.1 mg/kg) and the conditioned avoidance response in rats (ED50 = 0.8 mg/kg). It decreases basal prepulse inhibition of the acoustic startle response in rats by 42% when administered at a dose of 10 mg/kg.Formal Name: 7-[4-([1,1'-biphenyl]-3-ylmethyl)-1-piperazinyl]-2(3H)-benzoxazolone, monomethanesulfonate. CAS Number: 350992-13-1. Synonyms: DU 127090. Molecular Formula: C24H23N3O2 . CH3SO3H. Formula Weight: 481.6. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: soluble. lambdamax: 248 nm. SMILES: O=C1NC2=CC=CC(N3CCN(CC4=CC(C5=CC=CC=C5)=CC=C4)CC3)=C2O1.CS(=O)(O)=O. InChi Code: InChI=1S/C24H23N3O2.CH4O3S/c28-24-25-21-10-5-11-22(23(21)29-24)27-14-12-26(13-15-27)17-18-6-4-9-20(16-18)19-7-2-1-3-8-19,1-5(2,3)4/h1-11,16H,12-15,17H2,(H,25,28),1H3,(H,2,3,4). InChi Key: ONWKHSGOYGLGPO-UHFFFAOYSA-N.