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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
CDX-B0240-M025 | 25 mg | - | - |
3 - 9 business days* |
138.00€
|
||
CDX-B0240-M100 | 100 mg | - | - |
3 - 9 business days* |
413.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
(-)-Bicuculline methiodide is the N-methylated water-soluble derivative of the widely-employed... more
Product information "(-)-Bicuculline methiodide"
(-)-Bicuculline methiodide is the N-methylated water-soluble derivative of the widely-employed ionotropic GABAA receptor antagonist (+)-Bicuculline. This prototypic, competitive GABAA receptor antagonist displaces GABA from the agonist binding site to prevent receptor activation. It also acts as a negative allosteric inhibitor of channel opening to inhibit GABAA receptor activation by anaesthetic agents. Additionally it shows activity at SK calcium-activated potassium channels, nicotinic acetylcholine receptors and acetylcholinesterase. This compound reversibly and competitively blocks GABAA receptor mediated currents and is widely used to isolate glutamate receptor mediated EPSCs (excitatory postsynaptic potentials). Product References: (1) R.W. Olsen, et al., Brain Res. 102, 283 (1976) , (2) V. Seutin & S.W. Johnson, TiPS 20, 268 (1999) , (3) O. Chan, et al., Diabetes 55, 1080 (2006) , (4) S. Kurt, et al., Hear Res. 212, 224 (2006) , (5) G.A. Johnston, Br. J. Pharmacol. 169, 328 (2013) , (6) R.W. Olsen, Neuropharmacol. 136, 10 (2018) Appearance: White to off-white powder. Solubility: Soluble in water (10 mg/ml) or DMSO (30mg/ml). Identity: Determined by 1H-NMR. InChi Key: HKJKCPKPSSVUHY-GRTNUQQKSA-M Smiles: C[N+]1(C)[C@@]([C@@]2([H])C(C=CC3=C4OCO3)=C4C(O2)=O)([H])C5=CC6=C(OCO6)C=C5CC1.[I-]
Keywords: | N-Methylbicuculline iodide, 55950-07-7 |
Supplier: | Chemodex |
Supplier-Nr: | B0240 |
Properties
Application: | Water-soluble ionotropic GABAA receptor antagonist |
MW: | 509.29 D |
Formula: | C21H20INO6 |
Purity: | >95% (NMR) |
Format: | Solid |
Database Information
CAS : | 40709-69-1| Matching products |
KEGG ID : | K05175 | Matching products |
Handling & Safety
Storage: | +4°C |
Shipping: | +20°C (International: +20°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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