BI-9627

BI-9627 is an inhibitor of sodium-hydrogen exchanger isoform 1 (NHE1), with IC50 values of 6 and 31 nM in intracellular pH recovery (pHi) and human platelet swelling assays, respectively. It is greater than 30-fold selective for NHE1 over NHE2 and is inactive at NHE3 up to 16 µM in a pHi assay. BI-9627 inhibits phenylephrine-induced hypertrophy in neonatal rat cardiomyocytes. It increases recovery of left ventricular developed pressure and inhibits increases in left ventricular end-diastolic pressure (LVEDP) in a Langendorff isolated perfused rat heart model of ischemia-reperfusion injury when used at a concentration of 100 nM. BI-9627 (45 and 150 ppm in the diet) also attenuates decreases in left ventricular end-systolic pressure and increases in LVEDP in coronary artery-ligated rats.Formal Name: 4-(1-acetyl-4-piperidinyl)-N-(aminoiminomethyl)-3-(trifluoromethyl)-benzamide. CAS Number: 1204329-34-9. Molecular Formula: C16H19F3N4O2. Formula Weight: 356.3. Purity: >95% (mixture of tautomers). Formulation: (Request formulation change), A solid. Solubility: DMF: 10mg/mL, DMSO: 20mg/mL, DMSO:PBS (pH 7.2) (1:7): 0.12mg/mL. lambdamax: 244 nm. SMILES: CC(N(CC1)CCC1C2=CC=C(C(NC(N)=N)=O)C=C2C(F)(F)F)=O. InChi Code: InChI=1S/C16H19F3N4O2/c1-9(24)23-6-4-10(5-7-23)12-3-2-11(14(25)22-15(20)21)8-13(12)16(17,18)19/h2-3,8,10H,4-7H2,1H3,(H4,20,21,22,25). InChi Key: QMHRLXNEGYTSRV-UHFFFAOYSA-N.