Bezafibrate

Bezafibrate is a non-selective agonist of peroxisome proliferator-activated receptors (PPARs, EC50s = 50, 60, and 20 µM for human PPARalpha, PPARgamma, and PPARdelta, respectively). It reduces triglyceride levels and the size of lipid droplets in an oleic acid-induced HepaRG hepatocyte model of steatosis when used at a concentration of 25 µM. Bezafibrate (10 mg/kg per day) reduces plasma VLDL and LDL mass and triglyceride and free fatty acid levels in a high-fructose plus lard diet-induced rat model of insulin resistance.Formal Name: 2-[4-[2-[(4-chlorobenzoyl)amino]ethyl]phenoxy]-2-methyl-propanoic acid. CAS Number: 41859-67-0. Synonyms: Benzofibrate, BM 15075. Molecular Formula: C19H20ClNO4. Formula Weight: 361.8. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, DMSO:PBS (pH7.2)(1:1): 0.5 mg/ml, Ethanol: 3 mg/ml. lambdamax: 229 nm. SMILES: ClC1=CC=C(C(NCCC2=CC=C(OC(C)(C)C(O)=O)C=C2)=O)C=C1. InChi Code: InChI=1S/C19H20ClNO4/c1-19(2,18(23)24)25-16-9-3-13(4-10-16)11-12-21-17(22)14-5-7-15(20)8-6-14/h3-10H,11-12H2,1-2H3,(H,21,22)(H,23,24). InChi Key: IIBYAHWJQTYFKB-UHFFFAOYSA-N.