Bentamapimod

Bentamapimod is an orally bioavailable inhibitor of Jun kinases (JNKs), with IC50 values for JNK1, JNK2, and JNK3 of 80, 90, and 230 nM, respectively. It is selective for JNKs over a panel of 25 related kinases. Bentamapimod induces regression of endometriotic lesions without suppressing estrogen action in animal models of endometriosis. It blocks proliferation and induces apoptosis of T cells in vitro and inhibits cancer stem cell survival, self-renewal, and tumor-initiating capacity in vitro and in mice.Formal Name: alpha-[2-[[4-(4-morpholinylmethyl)phenyl]methoxy]-4-pyrimidinyl]-2-benzothiazoleacetonitrile. CAS Number: 848344-36-5. Synonyms: AS-602801. Molecular Formula: C25H23N5O2S. Formula Weight: 457.5. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 2 mg/ml, DMSO: 2 mg/ml. lambdamax: 217, 261, 387 nm. SMILES: N#CC(C1=NC2=C(C=CC=C2)S1)C3=NC(OCC4=CC=C(CN5CCOCC5)C=C4)=NC=C3. InChi Code: InChI=1S/C25H23N5O2S/c26-15-20(24-28-22-3-1-2-4-23(22)33-24)21-9-10-27-25(29-21)32-17-19-7-5-18(6-8-19)16-30-11-13-31-14-12-30/h1-10,20H,11-14,16-17H2. InChi Key: XCPPIJCBCWUBNT-UHFFFAOYSA-N.