Benoxaprofen

Benoxaprofen is a non-steroidal anti-inflammatory drug. It inhibits prostaglandin E2 (PGE2, Cay-14010) and leukotriene C4 (LTC4, Cay-20210) production in isolated mouse peritoneal macrophages stimulated with A23187 (Cay-11016, Cay-22030) when used at a concentration of 100 µM. Benoxaprofen (25 and 50 µg/ml) inhibits serum-induced chemotaxis of isolated rat peritoneal leukocytes. It induces hemolysis in isolated human erythrocytes and histamine release in isolated rat peritoneal mast cells in a light-dependent manner when used at a concentration of 10 µM. Benoxaprofen reduces carrageenan-induced paw edema and yeast-induced fever in rats and acetic acid-induced writhing in mice in a dose-dependent manner. Formulations containing benoxaprofen have previously been used in the treatment of osteoarthritis and rheumatoid arthritis.Formal Name: 2-(4-chlorophenyl)-alpha-methyl-5-benzoxazoleacetic acid. CAS Number: 51234-28-7. Synonyms: LRCL 3794, NSC 299582. Molecular Formula: C16H12ClNO3. Formula Weight: 301.7. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: slightly, Methanol: slightly, sonicated. SMILES: O=C(C(C)C1=CC=C2OC(C3=CC=C(Cl)C=C3)=NC2=C1)O. InChi Code: InChI=1S/C16H12ClNO3/c1-9(16(19)20)11-4-7-14-13(8-11)18-15(21-14)10-2-5-12(17)6-3-10/h2-9H,1H3,(H,19,20). InChi Key: MITFXPHMIHQXPI-UHFFFAOYSA-N.