Benfotiamine

Benfotiamine is a lipid-soluble form of vitamin B1 (thiamine). In vitro, it corrects defective replication of, and prevents formation of advanced glycosylation end products (AGEs) in, human umbilical vein endothelial cells (HUVECs) grown under high glucose conditions. In vivo, administration of benfotiamine increases nerve conduction velocity (NCV) and prevents microalbuminuria, proteinuria, and formation of AGEs in mice with streptozotocin-induced diabetes. Benfotiamine reduces liver levels of aspartate and alanine aminotransferases, markers of hepatic damage, and lipid peroxidation in a rat model of acute ethanol intoxication. Administration of benfotiamine reduces the number of amyloid plaques and amount of phosphorylated tau in a transgenic mouse model of Alzheimer's disease. It also improves spatial memory performance in the Morris water maze.Formal Name: benzenecarbothioic acid, S-[2-[[(4-amino-2-methyl-5-pyrimidinyl)methyl]formylamino]-1-[2-(phosphonooxy)ethyl]-1-propen-1-yl] ester. CAS Number: 22457-89-2. Synonyms: Benzoylthiamine monophosphate. Molecular Formula: C19H23N4O6PS. Formula Weight: 466.5. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: 0.1m NH4OH: 1 mg/ml, DMSO: slightly soluble. lambdamax: 243 nm. SMILES: C/C(N(CC1=CN=C(C)N=C1N)C=O)=C(SC(C2=CC=CC=C2)=O)\CCOP(O)(O)=O. InChi Code: InChI=1S/C19H23N4O6PS/c1-13(23(12-24)11-16-10-21-14(2)22-18(16)20)17(8-9-29-30(26,27)28)31-19(25)15-6-4-3-5-7-15/h3-7,10,12H,8-9,11H2,1-2H3,(H2,20,21,22)(H2,26,27,28)/b17-13-. InChi Key: BTNNPSLJPBRMLZ-LGMDPLHJSA-N.