BD 750

BD 750 is an immunosuppressant. It inhibits the proliferation of primary human and mouse T cells (IC50s = 1.1 and 1.5 µM, respectively) without inducing cytotoxicity when used at concentrations ranging from 3.13 to 50 µM. BD 750 induces cell cycle arrest at the G0/G1 phases in CD3 and CD28 antibody-activated primary human T cells when used at concentrations of 0.625, 2.5, and 10 µM and decreases the levels of cyclin D3 and cyclin-dependent kinase 6 (Cdk6) in CD3 and CD28 antibody-activated primary mouse T cells at 2.5 and 10 µM. It reduces the proliferation of IL-2-stimulated CTLL mouse T cells (IC50 = 1.2 µM) and decreases phosphorylated Stat5 levels in the same cells when used at concentrations of 5 and 20 µM. In vivo, BD 750 inhibits increases in ear thickness and ear patch weight in a mouse model of delayed-type hypersensitivity induced by 2,4-dinitrofluorobenzene.Formal Name: 2-(2-benzothiazolyl)-4,5,6,7-tetrahydro-2H-indazol-3-ol. CAS Number: 892686-59-8. Molecular Formula: C14H13N3OS. Formula Weight: 271.3. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 10 mg/ml, DMSO: 30 mg/ml, Ethanol: Slightly soluble. SMILES: OC1=C2C(CCCC2)=NN1C3=NC4=C(S3)C=CC=C4. InChi Code: InChI=1S/C14H13N3OS/c18-13-9-5-1-2-6-10(9)16-17(13)14-15-11-7-3-4-8-12(11)19-14/h3-4,7-8,18H,1-2,5-6H2. InChi Key: QCIFTVIFOWJGTB-UHFFFAOYSA-N.