BC-1382
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You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
BC-1382 is an inhibitor of the protein-protein interaction between E3 ubiquitin-protein ligase... more
Product information "BC-1382"
BC-1382 is an inhibitor of the protein-protein interaction between E3 ubiquitin-protein ligase HECTD2 and E3 SUMO-protein ligase PIAS1. It inhibits the HECTD2-PIAS1 protein-protein interaction (IC50 = ~5 nM in a pull-down assay) and increases the stability and levels of PIAS1. BC-1382 (10 mg/kg) decreases Tnf and Il-6 levels in bronchoalveolar lavage fluid (BALF) in mouse models of P. aeruginosa- or LPS-induced pneumonia.. Solulibility: DMSO: Sparingly soluble: 1-10 mg/ml: Ethanol: Sparingly soluble: 1-10 mg/ml.
| Keywords: | N-[(1S)-2-[[(2-methoxyphenyl)methyl]amino]-1-methyl-2-oxoethyl]-1-(phenylsulfonyl)-4-piperidinecarboxamide |
| Supplier: | Cayman Chemical |
| Supplier-Nr: | 43143 |
Properties
| Application: | HECTD2-PIAS1 protein-protein interaction inhibitor |
| MW: | 459.56 D |
| Formula: | C23H29N3O5S |
| Purity: | >98% |
| Format: | Solid |
Database Information
| CAS : | 1013753-99-5| Matching products |
| KEGG ID : | K12232 | Matching products |
Handling & Safety
| Storage: | -20°C |
| Shipping: | +20°C (International: -20°C) |
| Signal Word: | Warning |
| GHS Hazard Pictograms: |
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| H Phrases: | H302, H312, H315, H319, H332, H335 |
| P Phrases: | P261, P264, P270, P271, P280, P301+310, P302+352, P304+340, P305+351+338, P312, P321, P330, P332+313, P337+313, P361+364, P362+364, P403+233, P405, P501 |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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