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Item number: Cay43143-10

BC-1382 is an inhibitor of the protein-protein interaction between E3 ubiquitin-protein ligase HECTD2 and E3 SUMO-protein ligase PIAS1. It inhibits the HECTD2-PIAS1 protein-protein interaction (IC50 = ~5 nM in a pull-down assay) and increases the stability and levels of PIAS1. BC-1382 (10 mg/kg) decreases Tnf and...

Keywords:	N-[(1S)-2-[[(2-methoxyphenyl)methyl]amino]-1-methyl-2-oxoethyl]-1-(phenylsulfonyl)-4-piperidinecarboxamide
Application:	HECTD2-PIAS1 protein-protein interaction inhibitor
CAS	1013753-99-5
MW:	459.56 D

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BC-1382

Item number: TGM-T8564-100mg

Description: BC-1382 is a potent ubiquitin E3 ligase HECTD2 inhibitor that specifically disrupts the HECTD2/PIAS1 interaction(IC50 of 5 nM). Target: E1/E2/E3 Enzyme. Smiles: COc1ccccc1CNC(=O)C(C)NC(=O)C1CCN(CC1)S(=O)(=O)c1ccccc1. References: Coon T A , Mckelvey A C , Lear T , et al. The proinflammatory role of...

CAS	1013753-99-5
MW:	459.56 D

From 76.00€ *

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