BAY 57-1293

BAY-57-1293 is an orally bioavailable helicase-primase inhibitor. It inhibits the ATPase activity of herpes simplex virus (HSV) helicase-primase (IC50 = 30 nM). It inhibits HSV replication in Vero cells (IC50 = 20 nM for both HSV-1 and HSV-2) and is also active against porcine and bovine HSV strains (IC50s = 5 and 0.12 µM, respectively). In vivo, oral administration of BAY-57-1293 is effective against HSV-1 and HSV-2 in a lethal challenge model (ED50 = 0.5 mg/kg in mice and rats) and in a zosteriform spread model, at a dose of 15 mg/kg, in mice and Lewis rats. It is also effective in a guinea pig model of genital herpes and a mouse model of ocular herpes. BAY-57-1293 reduces levels of amyloid-beta (Abeta) and phosphorylated Tau in HSV-1 infected Vero cells.Formal Name: N-[5-(aminosulfonyl)-4-methyl-2-thiazolyl]-N-methyl-4-(2-pyridinyl)-benzeneacetamide. CAS Number: 348086-71-5. Synonyms: Pritelivir. Molecular Formula: C18H18N4O3S2. Formula Weight: 402.5. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml. lambdamax: 247, 283 nm. SMILES: O=C(N(C1=NC(C)=C(S(N)(=O)=O)S1)C)CC(C=C2)=CC=C2C3=NC=CC=C3. InChi Code: InChI=1S/C18H18N4O3S2/c1-12-17(27(19,24)25)26-18(21-12)22(2)16(23)11-13-6-8-14(9-7-13)15-5-3-4-10-20-15/h3-10H,11H2,1-2H3,(H2,19,24,25). InChi Key: IVZKZONQVYTCKC-UHFFFAOYSA-N.