BAY-2433334

BAY-2433334 is an inhibitor of Factor XIa (IC50 = 0.92 nM). It is greater than 1,000-fold selective for Factor Xa over FVIIa, FIXa, FXa, thrombin, urokinase, tissue plasminogen activator, and plasmin. BAY-2433334 increases clotting time in isolated human plasma (EC150 = 0.2 µM). In vivo, BAY-2433334 (10 and 30 mg/kg) reduces thrombus weight in a rabbit model of thrombosis induced by ferric chloride injury of the carotid artery.Formal Name: (alphaS)-N-[4-(aminocarbonyl)-3-fluorophenyl]-4-[5-chloro-2-[4-(trifluoromethyl)-1H-1,2,3-triazol-1-yl]phenyl]-alpha-ethyl-5-methoxy-2-oxo-1(2H)-pyridineacetamide. CAS Number: 2064121-65-7. Synonyms: Asundexian. Molecular Formula: C26H21ClF4N6O4. Formula Weight: 592.9. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: Sparingly Soluble: 1-10 mg/ml, Ethanol: Soluble: >10 mg/ml. SMILES: COC(C(C1=C(N2C=C(N=N2)C(F)(F)F)C=CC(Cl)=C1)=C3)=CN([C@@H](CC)C(NC4=CC(F)=C(C(N)=O)C=C4)=O)C3=O. InChi Code: InChI=1S/C26H21ClF4N6O4/c1-3-19(25(40)33-14-5-6-15(24(32)39)18(28)9-14)36-11-21(41-2)17(10-23(36)38)16-8-13(27)4-7-20(16)37-12-22(34-35-37)26(29,30)31/h4-12,19H,3H2,1-2H3,(H2,32,39)(H,33,40)/t19-/m0/s1. InChi Key: XYWIPYBIIRTJMM-IBGZPJMESA-N.