Bax Channel Blocker

Bax channel blocker is an inhibitor of Bax. It binds to Bax in a cell-free assay (Kd = 15 µM) and inhibits Bax-mediated membrane permeabilization induced by the membrane-targeted death ligand tBID in a liposomal release assay (IC50 = 3.3 µM). Bax channel blocker inhibits apoptosis induced by TNF-alpha- and the protein synthesis inhibitor cycloheximide (Cay-14126) in mouse embryonic fibroblasts (MEFs, IC50 = 1.8 µM). It also inhibits cell death induced by the Bax activator BTSA1 (Cay-37305) in OCI-AML-3 cells.Formal Name: 3,6-dibromo-alpha-(1-piperazinylmethyl)-9H-carbazole-9-ethanol. CAS Number: 335165-68-9. Synonyms: BAI1. Molecular Formula: C19H21Br2N3O. Formula Weight: 467.2. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 5 mg/ml, DMSO: 10 mg/ml, Ethanol: Slightly soluble. SMILES: BrC1=CC=C2C(C3=C(N2CC(CN4CCNCC4)O)C=CC(Br)=C3)=C1. InChi Code: InChI=1S/C19H21Br2N3O/c20-13-1-3-18-16(9-13)17-10-14(21)2-4-19(17)24(18)12-15(25)11-23-7-5-22-6-8-23/h1-4,9-10,15,22,25H,5-8,11-12H2. InChi Key: KUUJEXLRLIPQQJ-UHFFFAOYSA-N.