Batimastat

Batimastat is a broad spectrum inhibitor of matrix metalloproteinases (MMP), with IC50 values of 1-5 nM for all MMPs tested, including MMP-1, -2, -3, -7, -9, -13, and -14. It also potently inhibits TNFalpha-converting enzyme (IC50 = 14.9 nM). Because of its action on MMPs, batimastat has anti-proliferative, anti-invasive, and anti-metastatic actions that are relevant, in particular, to cancer. Batimastat less effectively inhibits the processing of the low affinity IgE receptor CD23 (IC50 = 100 nM).Formal Name: (2R,3S)-N4-hydroxy-N1-[(1S)-2-(methylamino)-2-oxo-1-(phenylmethyl)ethyl]-2-(2-methylpropyl)-3-[(2-thienylthio)methyl]-butanediamide. CAS Number: 130370-60-4. Synonyms: BB-94. Molecular Formula: C23H31N3O4S2. Formula Weight: 477.6. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 10 mg/ml, DMSO: 2 mg/ml. lambdamax: 269 nm. SMILES: O=C(N[C@@H](CC1=CC=CC=C1)C(NC)=O)[C@H](CC(C)C)[C@@H](C(NO)=O)CSC2=CC=CS2. InChi Code: InChI=1S/C23H31N3O4S2/c1-15(2)12-17(18(22(28)26-30)14-32-20-10-7-11-31-20)21(27)25-19(23(29)24-3)13-16-8-5-4-6-9-16/h4-11,15,17-19,30H,12-14H2,1-3H3,(H,24,29)(H,25,27)(H,26,28)/t17-,18+,19+/m1/s1. InChi Key: XFILPEOLDIKJHX-QYZOEREBSA-N.