Bamadutide

Bamadutide is a peptide agonist of glucagon receptor (GCGR) and glucagon-like peptide 1 receptor (GLP-1R). It induces cAMP accumulation in HEK293 cells expressing human GCGR or GLP-1R (EC50s = 1 and 3.5 pM, respectively). Bamadutide (0.1 mg/kg) reduces food intake in female mice. It decreases blood levels of glucose and hemoglobin A1c (HbA1c) in female db/db mice when administered at a dose of 0.1 mg/kg per day. Bamadutide (5 or 15 µg/kg twice per day) reduces body weight and total fat mass in male mice fed a high-fat diet.