74 products were found matching "K04583"!

A GCGR antagonist (IC50 = 15.7 nM), selective for GCGR over GIPR, GLP-1R, PAC1, VPAC1, and VPAC2 (IC50s = 1,020, >10,000, 9,200, 11,580, and 12,800 nM, respectively), reduces glucagon-induced increases in blood glucose levels in rhesus monkeys at 1 and 3 mg/kg. SMILES:...

Recombinant CHO-K1 cells stably overexpress human glucagon receptor (GCGR) on the surface and contain high levels of G protein Galphas to couple with the receptor in downstream signaling pathways.

Recombinant HEK293 cells stably overexpress human glucagon receptor (GCGR) on the surface and contain high levels of G protein Galphas to couple with the receptor in downstream signaling pathways.

The pancreatic hormone glucagon activates the glucagon receptor (GCGR), a class B seven-transmembrane G protein-coupled receptor that couples to the stimulatory heterotrimeric G protein and provokes PKA-dependent signaling cascades vital to hepatic glucose metabolism and islet insulin secretion. The GCGR expressed...

The pancreatic hormone glucagon activates the glucagon receptor (GCGR), a class B seven-transmembrane G protein-coupled receptor that couples to the stimulatory heterotrimeric G protein and provokes PKA-dependent signaling cascades vital to hepatic glucose metabolism and islet insulin secretion. The GCGR expressed...

Bamadutide is a peptide agonist of glucagon receptor (GCGR) and glucagon-like peptide 1 receptor (GLP-1R). It induces cAMP accumulation in HEK293 cells expressing human GCGR or GLP-1R (EC50s = 1 and 3.5 pM, respectively). Bamadutide (0.1 mg/kg) reduces food intake in female mice. It decreases blood levels of glucose...

A glucagon receptor antagonist

Adomeglivant is an allosteric antagonist of the glucagon receptor. It inhibits glucagon-induced increases in cAMP levels in HEK293 cells expressing the rat glucagon or GLP-1 receptors (IC50s = 1.8 and 1.2 µM, respectively) but has no effect on cAMP levels when used alone. Adomeglivant also inhibits increases in cAMP...

Glucagon receptor antagonist 3 is an antagonist of the glucagon receptor.Formal Name: (alphaR,4R)-rel-4-(4-fluoro-2-hydroxyphenyl)-alpha-methyl-2,6-bis(1-methylethyl)-5-propyl-3-pyridinemethanol. CAS Number: 202917-17-7. Molecular Formula: C22H30FNO2. Formula Weight: 359.5. Purity: >95%. Formulation: (Request...

Non-peptidic anti-diabetic agent, Receptor-selective glucagon antagonist, Free radical species (.OH, R.) and singlet oxygen (1O2) scavenger, Mycotoxin, Cytotoxic, Antioxidant. Isolated from fungus Talaromyces sp.

[Des-His1,Glu9]-Glucagon (1-29) amide is a peptide glucagon receptor antagonist (pA2 = 7.25 for glucagon binding to isolated rat liver membranes). It binds to glucagon receptors in a magnesium- and GTP-independent manner to stimulate breakdown of inositol phospholipids by phospholipase C, but has no effect on...

Glucagon receptor antagonist 4 is an antagonist of the glucagon receptor (GCGR, Ki = 14 nM for the human recombinant receptor). It is greater than 230-fold selective for GCGR over the glucagon-like peptide 1 (GLP-1) receptor, as well as a panel of 69 receptors, ion channels, uptake sites, and enzymes at 10 µM....