Azvudine

Description: Azvudine (FNC) is a potent nucleoside reverse transcriptase inhibitor (NRTI), with antiviral activity on HIV, HBV and HCV. Azvudine inhibits NRTI-resistant viral strains. Azvudine exerts highly potent inhibition on HIV-1 (EC50s ranging from 0.03 to 6.92 nM) and HIV-2 (EC50s ranging from 0.018 to 0.025 nM). Target: HCV Protease, HIV Protease, Reverse Transcriptase, HBV. Smiles: N(=[N+]=[N-])[C@]1(CO)O[C@H]([C@@H](F)[C@@H]1O)N2C(=O)N=C(N)C=C2. References: Wang RR, et al. Azvudine, a novel nucleoside reverse transcriptase inhibitor showed good drug combination features and better inhibition on drug-resistant strains than lamivudine in vitro. PLoS One. 2014 Aug 21,9(8):e105617.