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| Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
|---|---|---|---|---|---|---|---|
| Cay45751-1 | 1 mg | - |
5 - 10 business days* |
669.00€
|
|||
| Cay45751-5 | 5 mg | - |
5 - 10 business days* |
2,339.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
AZD 9750 is a proteolysis-targeting chimera (PROTAC) composed of an androgen receptor ligand and... more
Product information "AZD 9750"
AZD 9750 is a proteolysis-targeting chimera (PROTAC) composed of an androgen receptor ligand and a lenalidomide derivative. It induces the degradation of wild-type androgen receptor (AR) and drug-resistant mutant AR containing a leucine-to-histidine substitution at position 702 (ARL702H) with half-maximal degradation concentration (DC50) values of 10 and 12 nM, respectively. AZD 9750 (30 mg/kg) decreases tumor volume in a wild-type AR-expressing patient-derived xenograft (PDX) mouse model of prostate cancer.. SMILES: CN1C(C(CC2)CCN2CC(CC3)CCN3C(C=C4)=CC=C4[C@@H]5CCCN(C6=C7NN=C(C#N)C7=C(C=C6)Cl)C5)=CC8=CC=C(N9C(NC(CC9)=O)=O)C=C18. InChi Code: InChI=1S/C43H48ClN9O2/c1-49-38(23-31-6-9-34(24-39(31)49)53-22-16-40(54)46-43(53)55)30-14-18-50(19-15-30)26-28-12-20-51(21-13-28)33-7-4-29(5-8-33)32-3-2-17-52(27-32)37-11-10-35(44)41-36(25-45)47-48-42(37)41/h4-11,23-24,28,30,32H,2-3,12-22,26-27H2,1H3,(H,47,48)(H,46,54,55)/t32-/m1/s1. InChi Key: GOWJHJUMPVCHAN-JGCGQSQUSA-N
| Keywords: | 4-chloro-7-[(3S)-3-[4-[4-[[4-[1-methyl-6-(tetrahydro-2,4-dioxo-1(2H)-pyrimidinyl)-1H-indol-2-yl]-1-piperidinyl]methyl]-1-piperidinyl]phenyl]-1-piperidinyl]-1H-indazole-3-carbonitrile |
| Supplier: | Cayman Chemical |
| Supplier-Nr: | 45751 |
Properties
| Application: | Androgen receptor degradation driving PROTAC |
| MW: | 758.37 D |
| Formula: | C43H48ClN9O2 |
| Purity: | >98% |
| Format: | Solid |
Database Information
| CAS : | 3056515-10-4| Matching products |
| KEGG ID : | K08557 | Matching products |
Handling & Safety
| Storage: | -20°C |
| Shipping: | +20°C (International: -20°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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