AZD 8797

AZD 8797 is a chemokine (C-X3-C motif) receptor 1 (CX3CR1) antagonist (Ki = 3.9 nM). It is selective for CX3CR1 over CX3CR2 (Ki = 2,800 nM). AZD 8797 (0.1-10 µM) inhibits [35S]GTPgammaS accumulation induced by chemokine (C-X3-C) ligand 1 (CX3CL1) in CHO cell membranes expressing human CX3CR1. It inhibits adhesion of RBMI-8226 cells to CX3CL1 (IC50 = 5.8 nM). AZD 8797 (39 and 78 µmol/kg per day) reduces spinal cord inflammation and demyelination, as well as the incidence of disease relapse, in a rat model of myelin oligodendrocyte glycoprotein-induced experimental autoimmune encephalomyelitis (EAE).Formal Name: (2R)-2-[[2-amino-5-[[(1S)-1-phenylethyl]thio]thiazolo[4,5-d]pyrimidin-7-yl]amino]-4-methyl-1-pentanol. CAS Number: 911715-90-7. Molecular Formula: C19H25N5OS2. Formula Weight: 403.6. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: Soluble. lambdamax: 246 nm. SMILES: NC1=NC2=NC(S[C@@H](C)C3=CC=CC=C3)=NC(N[C@@H](CO)CC(C)C)=C2S1. InChi Code: InChI=1S/C19H25N5OS2/c1-11(2)9-14(10-25)21-16-15-17(22-18(20)27-15)24-19(23-16)26-12(3)13-7-5-4-6-8-13/h4-8,11-12,14,25H,9-10H2,1-3H3,(H3,20,21,22,23,24)/t12-,14+/m0/s1. InChi Key: ZMQSLMZOWVGBSM-GXTWGEPZSA-N.