AZD 5991

AZD 5991 is an inhibitor of myeloid cell leukemia-1 (Mcl-1, IC50 = 0.72 nM). It is selective for Mcl-1 over Bcl-2, Bcl-xL, Bcl-W, and Bfl-1 (IC50s = 20, 36, 49, and 24 µM, respectively). AZD 5991 decreases the viability of MV4-11 acute myeloid leukemia (AML) and MOLP-8 multiple myeloma (MM) cells with EC50 values of 24 and 33 nM, respectively. It disrupts formation of the Mcl-1-Bak complex and induces apoptosis in MOLP-8 cells when used at a concentration of 500 nM. AZD 5991 induces complete tumor regression in MV4-11 and MOLP-8 mouse xenograft models when administered at a single dose of 100 mg/kg.Formal Name: (3aR)-5-chloro-2,11,12,24,27,29-hexahydro-2,3,24,33-tetramethyl-22H-9,4,8-(metheniminomethyno)-14,20:26,23-dimetheno-10H,20H-pyrazolo[4,3-l][2,15,22,18,19]benzoxadithiadiazacyclohexacosine-32-carboxylic acid. CAS Number: 2143061-81-6. Molecular Formula: C35H34ClN5O3S2. Formula Weight: 672.3. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: 25 mg/ml, sonicated. SMILES: ClC1=C(C2=C(C)N(C)N=C2CSC3)C(N(C)C(C(O)=O)=C4CCCOC5=CC(SCC6=CC3=NN6C)=CC7=C5C=CC=C7)=C4C=C1. InChi Code: InChI=1S/C35H34ClN5O3S2/c1-20-31-29(38-40(20)3)19-45-17-22-15-23(41(4)37-22)18-46-24-14-21-8-5-6-9-25(21)30(16-24)44-13-7-10-26-27-11-12-28(36)32(31)33(27)39(2)34(26)35(42)43/h5-6,8-9,11-12,14-16H,7,10,13,17-19H2,1-4H3,(H,42,43). InChi Key: KBQCEQAXHPIRTF-UHFFFAOYSA-N.