AZD 0095

An MCT4 inhibitor (IC50 = 1.3 nM), selectively inhibits lactate influx in NCI H358 cells (IC50 = 6.1 nM), which highly express MCT4 and do not express MCT1, over lactate influx in K562 cells (IC50 = >30 µM), which highly express MCT1 and do not express MCT4, inhibits the proliferation of NCI H358 cells (IC50 = 26 nM), reduces tumor growth in an NCI H358 mouse xenograft model at 100 mg/kg twice per day in combination with cediranib. Formulation: A solid. InChI: InChI=1S/C27H32N8O2/c1-18-26(19(2)35-27(28-18)29-20(3)32-35)37-24-10-11-34(17-24)23-7-4-21(5-8-23)25-9-6-22(30-31-25)16-33-12-14-36-15-13-33/h4-9,24H,10-17H2,1-3H3/t24-/m1/s1. InChIKey: PHDAGSZQGNWGFE-XMMPIXPASA-N. SMILES: CC1=NC2=NC(C)=NN2C(C)=C1O[C@@H](C3)CCN3C(C=C4)=CC=C4C(N=N5)=CC=C5CN6CCOCC6