AZ 12216052

AZ 12216052 is a positive allosteric modulator of metabotropic glutamate receptor 8 (mGluR8). It potentiates glutamate-induced [35S]GTPgammaS binding in GHEK cells expressing human mGluR8b (EC50 = 1 µM). In a cell-based model of Parkinson's disease, AZ 12216052 inhibits MPP+-induced decreases in the viability of undifferentiated SH-SY5Y cells when used at concentrations ranging from 0.001 to 1 µM and in retinoic acid-differentiated SH-SY5Y cells at 0.1 and 1 µM. AZ 12216052 (10 mg/kg) increases the time spent in the open areas of the elevated zero maze and reduces the acoustic startle response in mice, indicating anxiolytic-like activity in response to avoidable and unavoidable anxiogenic stimuli, respectively.Formal Name: 2-[[(4-bromophenyl)methyl]thio]-N-[4-(1-methylpropyl)phenyl]-acetamide. CAS Number: 1290628-31-7. Molecular Formula: C19H22BrNOS. Formula Weight: 392.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: soluble. lambdamax: 230, 248 nm. SMILES: BrC1=CC=C(CSCC(NC2=CC=C(C(C)CC)C=C2)=O)C=C1. InChi Code: InChI=1S/C19H22BrNOS/c1-3-14(2)16-6-10-18(11-7-16)21-19(22)13-23-12-15-4-8-17(20)9-5-15/h4-11,14H,3,12-13H2,1-2H3,(H,21,22). InChi Key: QKUYZJOTWYRWNF-UHFFFAOYSA-N.