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Item number: TGM-T26701-100mg

Description: AZ12216052 is a GRP8 antagonist with anxiolytic and anti-inflammatory activity and can be used to study obesity and metabolic disorders. Target: GPR. Smiles: CCC(C)c1ccc(NC(=O)CSCc2ccc(Br)cc2)cc1. References: Reed BT, et al. Differential modulation of retinal ganglion cell light responses by orthosteric...

Keywords:	AZ 12216052, AZ-12216052
CAS	1290628-31-7
MW:	392.35 D

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AZ 12216052

Item number: Cay29460-1

AZ 12216052 is a positive allosteric modulator of metabotropic glutamate receptor 8 (mGluR8). It potentiates glutamate-induced [35S]GTPgammaS binding in GHEK cells expressing human mGluR8b (EC50 = 1 µM). In a cell-based model of Parkinson's disease, AZ 12216052 inhibits MPP+-induced decreases in the viability of...

Keywords:	2-[[(4-bromophenyl)methyl]thio]-N-[4-(1-methylpropyl)phenyl]-acetamide
Application:	mGluR8 positive allosteric modulator
CAS	1290628-31-7
MW:	392.4 D

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