AXC-715 (hydrochloride)
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You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
AXC-715 is a dual agonist of toll-like receptor 7 (TLR7) and TLR8. It activates NF-kappaB in a... more
Product information "AXC-715 (hydrochloride)"
AXC-715 is a dual agonist of toll-like receptor 7 (TLR7) and TLR8. It activates NF-kappaB in a secreted alkaline phosphatase (SEAP) assay using TLR7- or TLR8-expressing HEK293 cells (EC50s = 0.634 and 1.3 µM, respectively). AXC-715 has been linked to the anti-HER2 antibody trastuzumab as an antibody-drug conjugate (ADC). AXC-715 linked to trastuzumab reduces tumor volume in an HCC1954 breast cancer mouse xenograft model. SMILES NC1=NC2=CC=CC=C2C3=C1N=C(CCCC)N3CCCCN.Cl.Cl.Cl InChi Code InChI=1S/C18H25N5.3ClH/c1-2-3-10-15-22-16-17(23(15)12-7-6-11-19)13-8-4-5-9-14(13)21-18(16)20,,,/h4-5,8-9H,2-3,6-7,10-12,19H2,1H3,(H2,20,21),3*1H InChi Key ZSUHKPUPLPQJGC-UHFFFAOYSA-N
| Keywords: | T785, 4-amino-2-butyl-1H-imidazo[4,5-c]quinoline-1-butanamine, trihydrochloride |
| Supplier: | Cayman Chemical |
| Supplier-Nr: | 44007 |
Properties
| Application: | TLR7 / TLR8 dual agonist |
| MW: | 420.8 D |
| Formula: | C18H25N5 . 3HCl |
| Purity: | >95% |
| Format: | Solid |
Database Information
| CAS : | 2479276-17-8| Matching products |
| KEGG ID : | K05404 | Matching products |
Handling & Safety
| Storage: | -20°C |
| Shipping: | +20°C (International: -20°C) |
| Signal Word: | Warning |
| GHS Hazard Pictograms: |
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| H Phrases: | H302, H315, H319, H335 |
| P Phrases: | P261, P264, P270, P271, P280, P301+310, P302+352, P304+340, P305+351+338, P312, P321, P330, P332+313, P337+313, P362+364, P403+233, P405, P501 |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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