AVE-1231

An inhibitor of K2P3.1/TASK1, reduces potassium currents in X. laevis oocytes expressing TASK1 or Kv1.5 (IC50s = 0.22 and 5.6 µM, respectively), restores sinus rhythm in a porcine model of acute paroxysmal atrial fibrillation at 1 mg/kg, reduces the severity of EAE in wild-type mice but not TASK1 knockout mice at 0.02 mg/kg. SMILES: CC[C@H](C1=CN=C(OC)C=C1)NC(C(C=CC=C2)=C2NS(CCCC)(=O)=O)=O. InChi Code: InChI=1S/C20H27N3O4S/c1-4-6-13-28(25,26)23-18-10-8-7-9-16(18)20(24)22-17(5-2)15-11-12-19(27-3)21-14-15/h7-12,14,17,23H,4-6,13H2,1-3H3,(H,22,24)/t17-/m1/s1. InChi Key: BFQMQSIBOHOPCY-QGZVFWFLSA-N